The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.

Abstract

Estrogens attenuate osteoclastogenesis and stimulate osteoclast apoptosis, but the molecular mechanism and contribution of these effects to the overall antiosteoporotic efficacy of estrogens remain controversial. We selectively deleted the estrogen receptor (ER)alpha from the monocyte/macrophage cell lineage in mice (ERalpha(LysM)(-/-)) and found a 2-fold… (More)
DOI: 10.1210/me.2009-0354

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@article{MartinMillan2010TheER, title={The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.}, author={Marta Martin-Millan and Maria Teresa Almeida and Elena Ambrogini and Li Han and Haibo Zhao and Robert Weinstein and Robert L. Jilka and C A O'brien and Stavros C Manolagas}, journal={Molecular endocrinology}, year={2010}, volume={24 2}, pages={323-34} }