The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

@article{Issa1996TheER,
  title={The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.},
  author={Jean-Pierre Issa and Barbara A. Zehnbauer and Curt I. Civin and Michael I. Collector and Saul J. Sharkis and Nancy E. Davidson and Scott H. Kaufmann and Stephen B. Baylin},
  journal={Cancer research},
  year={1996},
  volume={56 5},
  pages={973-77}
}
Estrogen appears to be a negative regulator of normal hematopoiesis. Chromosome 6q, which contains the estrogen receptor (ER) gene, is frequently altered in human hematopoietic neoplasms. The ER gene, which has growth and metastasis suppressor activity in many different cell types, is inactivated by promoter methylation in some ER-negative breast tumors and 100% of colorectal tumors. We now report that the promoter region of the ER gene is aberrantly methylated in 86% of human hematopoietic… CONTINUE READING

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