The estimation of linkage from the offspring of selfed heterozygotes

  title={The estimation of linkage from the offspring of selfed heterozygotes},
  author={Ronald Aylmer Sir Fisher and Bhai Balmukand},
  journal={Journal of Genetics},
SummaryFive methods of solution are given of the statistical problem presented by typical linkage data. The example chosen shows the various errors into which the use of inefficient statistics leads. Of the efficient methods the method of maximum likelihood possesses the advantage that it may be applied directly to any analogous problem, and is related in a previously unsuspected way to the measure of discrepancyX2. The product ratio method, for using which a table is provided, enjoys the… 
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The probable errors of calculated linkage values, and the most accurate method of determining gametic from certain zygotic series
A method is given by which the best possible linkage values may be calculated from the offspring of the latter two crosses, i.e. from F2, which is almost as accurate a means of measuring linkage as are the offspring fromF1 × double recessive.
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It has been pointed out to me that some of the statistical ideas employed in the following investigation have never received a strictly logical definition and analysis, and it is desirable to set out for criticism the manner in which the logical foundations of these ideas may be established.
On the Mathematical Foundations of Theoretical Statistics
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A Genetic Study of Certain Chlorophyll Deficiencies in Maize.
A genetic study of certain chlorophyll deficiencies in maize shows signs of being passed off to other crops by the immune system through various mechanisms, including “cell reprograming” and “self-consistency”.
" T h e chromosome hypothesis of linkage
  • 1914