The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases.

@article{Lin2011TheER,
  title={The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases.},
  author={Qing Lin and Mingcai Li and Dan Fang and Jiazhu Fang and Shao Bo Su},
  journal={International immunopharmacology},
  year={2011},
  volume={11 10},
  pages={1422-32}
}
Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing pro-inflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. Inappropriate activation of TLRs by self-components… CONTINUE READING