The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.

@article{Shen2009TheER,
  title={The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.},
  author={Shudan Shen and Minghua Zhu and Jasmine Lau and Mariana I Chuck and Weiguo Zhang},
  journal={Journal of immunology},
  year={2009},
  volume={182 9},
  pages={5596-604}
}
The linker for activation of T cells (LAT) is an adaptor protein that couples TCR engagement to downstream signaling cascades. LAT is important in early thymocyte development as LAT-deficient mice have a complete block at the double-negative (DN) 3 stage. To study the role of LAT beyond the DN3 stage, we generated mice in which the lat gene could be deleted by the Cre recombinase. Analysis of these mice showed that deletion of LAT after the DN3 stage allowed thymocytes to develop past the DN3… CONTINUE READING

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