The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain

@inproceedings{Wright2012TheER,
  title={The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain},
  author={Amanda L. Wright and Bryce Vissel},
  booktitle={Front. Mol. Neurosci.},
  year={2012}
}
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are comprised of different combinations of GluA1-GluA4 (also known asGluR1-GluR4 and GluR-A to GluR-D) subunits. The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA. AMPA receptors are calcium (Ca(2+))-permeable if they contain the unedited GluA2(Q) subunit or if they lack the GluA2 subunit… CONTINUE READING
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