The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi.

@article{Byram2004TheEN,
  title={The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi.},
  author={Rebecca Byram and Philip E Stewart and Patricia A Rosa},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 11},
  pages={3561-9}
}
The genome of the type strain (B31) of Borrelia burgdorferi, the causative agent of Lyme disease, is composed of 12 linear and 9 circular plasmids and a linear chromosome. Plasmid content can vary among strains, but one 26-kb circular plasmid (cp26) is always present. The ubiquitous nature of cp26 suggests that it provides functions required for bacterial viability. We tested this hypothesis by attempting to selectively displace cp26 with an incompatible but replication-proficient vector… CONTINUE READING
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