The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae.

@article{Geiser1993TheEM,
  title={The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae.},
  author={Jim Geiser and Holly A Sundberg and Benny Hung-Junn Chang and Eric G. D. Muller and T. N. Davis},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 12},
  pages={7913-24}
}
Two independent methods identified the spindle pole body component Nuf1p/Spc110p as the essential mitotic target of calmodulin. Extragenic suppressors of cmd1-1 were isolated and found to define three loci, XCM1, XCM2, and XCM3 (extragenic suppressor of cmd1-1). The gene encoding a dominant suppressor allele of XCM1 was cloned. On the basis of DNA sequence analysis, genetic cosegregation, and mutational analysis, XCM1 was identified as NUF1/SPC110. Independently, a C-terminal portion of Nuf1p… CONTINUE READING
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