The essential genome of a bacterium

  title={The essential genome of a bacterium},
  author={Beat Christen and Eduardo Abeliuk and John Michael Collier and Virginia S. Kalogeraki and Ben Passarelli and John A. Coller and Michael J. Fero and Harley H. McAdams and Lucy Shapiro},
  booktitle={Molecular systems biology},
Caulobacter crescentus is a model organism for the integrated circuitry that runs a bacterial cell cycle. Full discovery of its essential genome, including non-coding, regulatory and coding elements, is a prerequisite for understanding the complete regulatory network of a bacterial cell. Using hyper-saturated transposon mutagenesis coupled with high-throughput sequencing, we determined the essential Caulobacter genome at 8 bp resolution, including 1012 essential genome features: 480 ORFs, 402… CONTINUE READING
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