The essential function of the MRN complex in the resolution of endogenous replication intermediates.

@article{Bruhn2014TheEF,
  title={The essential function of the MRN complex in the resolution of endogenous replication intermediates.},
  author={Christopher Bruhn and Zhong-Wei Zhou and Haiyan Ai and Zhao-Qi Wang},
  journal={Cell reports},
  year={2014},
  volume={6 1},
  pages={182-95}
}
The MRN complex (Mre11/Rad50/Nbs1) is important in double-strand break (DSB) recognition, end resection, replication fork stabilization, and ATM and ATR activation. Complete deletion of MRN is incompatible with cell and organism life, presumably due to replication-born DSBs; however, the underlying mechanism remains unknown. We devised a noninvasive high-content assay, termed high-content microscopy-assisted cell-cycle phenotyping (hiMAC), to investigate the fate of cells lacking Nbs1… CONTINUE READING
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