The essential function of genes for a hydratase and an aldehyde dehydrogenase for growth of Pseudomonas sp. strain Chol1 with the steroid compound cholate indicates an aldolytic reaction step for deacetylation of the side chain.

@article{Holert2013TheEF,
  title={The essential function of genes for a hydratase and an aldehyde dehydrogenase for growth of Pseudomonas sp. strain Chol1 with the steroid compound cholate indicates an aldolytic reaction step for deacetylation of the side chain.},
  author={Johannes Holert and Nina Jagmann and Bodo Philipp},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 15},
  pages={3371-80}
}
In the bacterial degradation of steroid compounds, the enzymes initiating the breakdown of the steroid rings are well known, while the reactions for degrading steroid side chains attached to C-17 are largely unknown. A recent in vitro analysis with Pseudomonas sp. strain Chol1 has shown that the degradation of the C5 acyl side chain of the C24 steroid compound cholate involves the C22 intermediate 7α,12α-dihydroxy-3-oxopregna-1,4-diene-20S-carbaldehyde (DHOPDCA) with a terminal aldehyde group… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Molecular characterization of ltp3 and ltp4, essential for C24-branched chain sterol-sidechain degradation in Rhodococcus rhodochrous DSM 43269

  • MH Wilbrink, R van der Geize, L. Dijkhuizen
  • Microbiology
  • 2012
2 Excerpts

Similar Papers

Loading similar papers…