The essence of inactivity

@article{Davies1991TheEO,
  title={The essence of inactivity},
  author={Kevin Davies},
  journal={Nature},
  year={1991},
  volume={349},
  pages={15-16}
}
  • K. Davies
  • Published 3 January 1991
  • Philosophy
  • Nature
Assignment By R-Banding Of X-Inactivation Status For A Patient With A Sex Chromosome Abnormality
TLDR
The results demonstrate that the patient’s normal X chromosome was early replicating as well as the duplicated region of the abnormal X chromosome, suggesting that the observed phenotype is a result of incomplete inactivation of the duplicates X chromosome.
Les troubles psychiatriques dans le syndrome de Klinefelter. Quels liens
Le syndrome de Klinefelter, pathologie d’origine genetique caracterisee par la presence d’un chromosome X supplementaire (47XXY) touche pres d’1 garcon sur 500. Il est defini par un retard pubertaire
Mammalian-type dosage compensation mechanism in an insect —Gryllotalpa fossor (Scudder) — Orthoptera
TLDR
D dosage compensation in Gryllotalpa seems to be analogous to that in mammals, and it is implied that the restoration of X chromosome inactivation should occur some time during early embryogenesis.
Absence of Z-chromosome inactivation for five genes in male chickens
TLDR
Results suggest strongly that Z-chromosome inactivation, i.e. virtual silence of transcription at one of the alleles, does not take place for these five Z-linked genes in male chickens.
Allele sharing for schizophrenia and schizo-affective disorder within a region of Homo sapiens specific XY homology.
TLDR
It is concluded that this region does not include a gene predisposing to psychosis or that if it does, the relevant variation is epigenetic rather than sequence-based and the recent evolutionary history of the Xq21.3/Yp region may be epigenetically labile.
Effects of human X and Y chromosomes on oral and craniofacial morphology : studies of 46,XY females, 47,XYY males and 45,X/46,XX females
TLDR
The results show that the presence of the Y chromosome in 46,XY females and the supernumerary Y chromosomal gene(s) in 47,XYY males result in the enlargement of the dental arches and craniofacial dimensions without substantial effects on dimensional ratios and plane angles, but with special influence on the growth of the mandibular corpus.
The Human Genome: Chromosomes
TLDR
Cytogenetics of animals and plants flourished during the first half of the century, and almost all important phenomena in the field of cytogenetics were discovered during this period.
Characterization of the promoter region of human steriod sulfatase: A gene which escapes X inactivation
TLDR
The human X-linked steroid sulfatase gene (STS) was among the first genes shown to escape X inactivation and studies of the promoters of these genes could provide insights into the mechanism of X in activation, however little information of this nature is currently available.
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TLDR
A cDNA library was constructed from poly(A)+ RNA derived from MP2H4, a mousehuman somatic cell hybrid, containing as its only human contribution an X-6 translocation chromosome, which hybridized more strongly with cDNA derived from the mouse-human hybrid than with the mouse only cell line.
Isolation and characterization of a steroid sulfatase cDNA clone: genomic deletions in patients with X-chromosome-linked ichthyosis.
TLDR
Clone p422 has a coincident localization with the previously identified locus for steroid sulfatase expression in the region of the X chromosome escaping from inactivation, which is deficient in classical X-chromosome-linked ichthyosis patients.
Localization of a gene that escapes inactivation to the X chromosome proximal short arm: implications for X inactivation.
TLDR
The A1S9T gene, an X-linked locus that complements a mouse temperature-sensitive defect in DNA synthesis, escapes inactivation and has now been localized, in human-mouse somatic cell hybrids, to the proximal short arm of the X chromosome.
The primary structure of rat ribosomal protein S4.
Localization of the X inactivation centre on the human X chromosome in Xq13
TLDR
An analysis of several rearranged human X chromosomes is reported and a minimal region of overlap is defined that is consistent with models invoking a single XIC and provide a molecular foothold for cloning and analysing the XIC region.
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
TLDR
This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern.
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
TLDR
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
TLDR
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
A Drosophila Minute gene encodes a ribosomal protein
TLDR
It is reported here that transformation with a cloned 3.3-kilobase region containing the gene encoding the large subunit ribosomal protein 49 (rp49) suppresses the dominant phenotypes of Minute (3)99D, a previously undescribed Minute associated with a chromosomal deficiency of the 99D interval.
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