The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.

@article{Drissen2005TheEP,
  title={The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.},
  author={Roy Drissen and Marieke von Lindern and Andrea Kolbus and Siska Driegen and Peter Steinlein and Hartmut Beug and Frank Grosveld and Sjaak Philipsen},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 12},
  pages={5205-14}
}
Development of red blood cells requires the correct regulation of cellular processes including changes in cell morphology, globin expression and heme synthesis. Transcription factors such as erythroid Kruppel-like factor EKLF (Klf1) play a critical role in erythropoiesis. Mice lacking EKLF die around embryonic day 14 because of defective definitive erythropoiesis, partly caused by a deficit in beta-globin expression. To identify additional target genes, we analyzed the phenotype and gene… CONTINUE READING
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