The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.

@article{Nai2014TheEF,
  title={The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.},
  author={Antonella Nai and Rosa Maria Pellegrino and Marco Rausa and Alessia Pagani and Martina Boero and Laura Silvestri and Giuseppe Saglio and A Roetto and Clara Camaschella},
  journal={Haematologica},
  year={2014},
  volume={99 6},
  pages={1016-21}
}
Transferrin receptor 2 (TFR2) is a transmembrane glycoprotein expressed in the liver and in the erythroid compartment, mutated in a form of hereditary hemochromatosis. Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the erythropoietin receptor complex. The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency… CONTINUE READING