The erbB3 gene product is a receptor for heregulin.

  title={The erbB3 gene product is a receptor for heregulin.},
  author={Kermit L. Carraway and Mark X. Sliwkowski and Robert W. Akita and Jill V. Platko and Pamela M Guy and A Nuijens and A John Diamonti and Richard L. Vandlen and Lewis C. Cantley and Richard A. Cerione},
  journal={The Journal of biological chemistry},
  volume={269 19},
ErbB3 is a member of the epidermal growth factor (EGF) receptor subfamily of receptor tyrosine kinases and is believed to be a receptor for an unknown ligand. We have tested the possibility that heregulin, a growth factor possessing an EGF-like domain, is a ligand for ErbB3. We have found that the iodinated recombinant EGF-like domain of heregulin-beta 1 (125I-rHRG beta 1(177-244) bound specifically to insect cell-expressed bovine ErbB3 with a dissociation constant of 0.85 nM. Moreover, 125I… CONTINUE READING
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