The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.

@article{Teichman2009TheEO,
  title={The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.},
  author={Shlomit Teichman and Shaogang Qu and Baruch I. Kanner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 34},
  pages={14297-302}
}
Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. Their transport cycle consists of two separate translocation steps, namely cotransport of glutamic acid with three Na(+) followed by countertransport of K(+). Two Tl(+) binding sites, presumed to serve as sodium sites, were observed in the crystal structure of a related archeal homolog and the side chain of a conserved aspartate residue contributed to one of these sites. We… CONTINUE READING

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