The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar

@article{Taylor1999TheEA,
  title={The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar},
  author={Jenny C. Taylor and David Raymond Ferry and Christopher F. Higgins and Richard Callaghan},
  journal={British Journal of Cancer},
  year={1999},
  volume={81},
  pages={783 - 789}
}
The gene encoding the multidrug resistance P-glycoprotein (P-gp) is duplicated in rodent species and the functional basis for this remains unresolved. Despite a high sequence similarity, the mouse P-gp1a and P-gp1b isoforms show distinct patterns of tissue distribution which suggest a specific role of the P-gp1b isoform in steroid transport. In the present study possible biochemical differences between the isoforms were directly investigated at the level of drug interaction. There was no… CONTINUE READING
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Pharmacologic Analysis of Drug-Receptor Interaction pp. 198–241

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