Corpus ID: 37616980

The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation.

  title={The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation.},
  author={B. Doble and P. Ping and E. Kardami},
  journal={Circulation research},
  volume={86 3},
  • B. Doble, P. Ping, E. Kardami
  • Published 2000
  • Medicine
  • Circulation research
  • Gap junctions (GJs), composed of connexins, are intercellular channels ensuring electric and metabolic coupling between cardiomyocytes. We have shown previously that an endogenous mitogenic and cardioprotective protein, fibroblast growth factor-2 (FGF-2), decreases cardiomyocyte GJ permeability by stimulating phosphorylation of connexin-43 (Cx43). Identifying the kinase(s) phosphorylating cardiac Cx43 may thus provide a way of modulating cardiac intercellular communication. Because FGF-2… CONTINUE READING
    Plasma membrane channels formed by connexins: their regulation and functions.
    • 987
    • Open Access
    The effects of connexin phosphorylation on gap junctional communication.
    • 546
    • Open Access
    Connexin phosphorylation as a regulatory event linked to gap junction channel assembly.
    • 274
    • Open Access
    Connexins: a myriad of functions extending beyond assembly of gap junction channels
    • 214
    • Open Access
    The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth
    • 125
    Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes
    • 116
    • Open Access
    Translocation of Protein Kinase C Isoforms to Subcellular Targets in Ischemic and Anesthetic Preconditioning
    • 138
    • Highly Influenced
    • Open Access