Corpus ID: 37616980

The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation.

@article{Doble2000TheES,
  title={The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation.},
  author={B. Doble and P. Ping and E. Kardami},
  journal={Circulation research},
  year={2000},
  volume={86 3},
  pages={
          293-301
        }
}
  • B. Doble, P. Ping, E. Kardami
  • Published 2000
  • Medicine
  • Circulation research
  • Gap junctions (GJs), composed of connexins, are intercellular channels ensuring electric and metabolic coupling between cardiomyocytes. We have shown previously that an endogenous mitogenic and cardioprotective protein, fibroblast growth factor-2 (FGF-2), decreases cardiomyocyte GJ permeability by stimulating phosphorylation of connexin-43 (Cx43). Identifying the kinase(s) phosphorylating cardiac Cx43 may thus provide a way of modulating cardiac intercellular communication. Because FGF-2… CONTINUE READING
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