The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.

Abstract

Antifilaggrin autoantibodies (AFA) are a population of IgG autoantibodies associated to rheumatoid arthritis (RA), which includes the so-called "antikeratin" Abs and antiperinuclear factor. AFA are the most specific serological markers of RA. We previously showed that they recognize human epidermal filaggrin and other profilaggrin-related proteins of… (More)

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Cite this paper

@article{GirbalNeuhauser1999TheET, title={The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.}, author={Elisabeth Girbal-Neuhauser and Jenni Durieux and M. Arnaud and Pascal Dalbon and Mireille Sebbag and C. Vincent and M. Simon and Tatsuo Senshu and C Masson-Bessi{\`e}re and Colette Jolivet-Reynaud and M. Jolivet and Gilles Serre}, journal={Journal of immunology}, year={1999}, volume={162 1}, pages={585-94} }