The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins).

@article{Hrkk1997TheEF,
  title={The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins).},
  author={Sohvi H{\"o}rkk{\"o} and Eric Miller and David Ware Branch and Wulf Palinski and Joseph L. Witztum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 19},
  pages={10356-61}
}
Circulating autoantibodies to phospholipids (aPLs), such as cardiolipin (CL), are found in patients with antiphospholipid antibody syndrome (APS). We recently demonstrated that many aPLs bound to CL only after it had been oxidized (OxCL), but not to a reduced CL analogue that could not undergo oxidation. We now show that the neoepitopes recognized by some aPLs consist of adducts formed between breakdown products of oxidized phospholipid and associated proteins, such as beta2 glycoprotein 1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.

Hörkkö et al

T. Olee, S. S. Pierangeli, +11 authors 8606–8611. Medical Sciences
Proc. Natl. Acad. Sci. USA 94 • 1997
View 1 Excerpt

Similar Papers

Loading similar papers…