The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate.

@article{Beckman1987TheEO,
  title={The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate.},
  author={Wendy Beckman and J L Camps and R. H. Weissman and Stephen L. Kaufman and S J Sanofsky and Robert Lee Reddick and Gene P. Siegal},
  journal={The American journal of pathology},
  year={1987},
  volume={128 3},
  pages={555-65}
}
Dunning R3327-H rat prostate adenocarcinoma cells, when grown in syngeneic (Copenhagen) rats or nude mice, produce tumors with prominent hypercellular stroma. The authors have previously demonstrated the presence of anomalous steroid-sensitive cells in both the epithelium and stromal compartments of this model system. In order to better understand the histogenesis of these cells, the authors studied samples of the tumor which were radiolabeled overnight with tritiated dihydrotestosterone (3H… CONTINUE READING