The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies.

@article{Gttlinger1986TheEC,
  title={The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies.},
  author={H G G{\"o}ttlinger and Ilona Funke and Judith P. Johnson and Josef Michael Gokel and Gert Riethmueller},
  journal={International journal of cancer},
  year={1986},
  volume={38 1},
  pages={47-53}
}
The antigen defined by MAb 17-1A, raised against colorectal cancer cells and currently used in immunotherapy trials, is a 37 kDa protein containing N-linked glycans as demonstrated by inhibition of glycosylation with tunicamycin. The 17-1A antigen (17-1A Ag) is broadly distributed in normal epithelial tissues and is also found in various types of carcinoma. Quantitative differences in expression between normal and malignant tissues were only apparent in gastric carcinomas. After immunizing mice… CONTINUE READING

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