The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium.

@article{Hoenderop1999TheEC,
  title={The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium.},
  author={Joost G. J. Hoenderop and Annemiete W C M van der Kemp and Anita den Hartog and C. H. van Os and Peter H G M Willems and Ren{\'e} J M Bindels},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 2},
  pages={488-92}
}
The recently cloned epithelial Ca(2+) channel, ECaC, which is expressed in the apical membrane of 1,25-dihydroxyvitamin D(3)-responsible epithelia, was characterized in Xenopus laevis oocytes by measuring the Ca(2+)-activated Cl(-) current which is a sensitive read-out of the Ca(2+) influx. ECaC-expressing oocytes responded to a voltage ramp with a maximal inward current of -2.1 +/- 0.3 microA at a holding potential of -99 +/- 1 mV. The inward current decreased progressively at less negative… CONTINUE READING

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