The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.

@article{Eerden2005TheEC,
  title={The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption.},
  author={Bram C. J. van der Eerden and Joost G. J. Hoenderop and Teun J de Vries and Ton A M Schoenmaker and Cok J. Buurman and Andr{\'e} G. Uitterlinden and Huibert A. P. Pols and Ren{\'e} J M Bindels and Johannes P T M van Leeuwen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 48},
  pages={17507-12}
}
Bone remodeling involves the interplay of bone resorption and formation and is accurately controlled to maintain bone mass. Both processes require transcellular Ca(2+) transport, but the molecular mechanisms engaged remain largely elusive. The epithelial Ca(2+) channel TRPV5 is one of the most Ca(2+)-selective transient receptor potential (TRP) channels. In this study, the functional role of TRPV5 in bone was investigated. TRPV5 mRNA was expressed in human and murine bone samples and in… CONTINUE READING

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