The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells

@inproceedings{Chen2013TheEM,
  title={The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells},
  author={Xuechen Chen and Wei Xiao and W. Chen and Lixia Luo and Shaobi Ye and Ying-xi Liu},
  booktitle={Cell Death and Disease},
  year={2013}
}
Proliferation and epithelial–mesenchymal transition (EMT) of lens epithelium cells (LECs) may contribute to anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Histone deacetylases (HDACs)-mediated epigenetic mechanism has a central role in controlling cell cycle regulation, cell proliferation and differentiation in a variety of cells and the pathogenesis of some diseases. However, whether HDACs are involved in the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Prevention of posterior capsular opacification.

Experimental eye research • 2015
View 6 Excerpts
Highly Influenced

Epigenetic Regulation of Skin Development and Regeneration

Stem Cell Biology and Regenerative Medicine • 2018
View 14 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Histone deacetylases and cancer.

Molecular oncology • 2012
View 3 Excerpts
Highly Influenced

EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 2006
View 17 Excerpts
Highly Influenced

Transforming growth factorbeta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs

RU de Iongh, E Wederell, FJ Lovicu, JW. McAvoy
2005
View 7 Excerpts
Highly Influenced

Effect of cataract surgery on aqueous TGF-beta and lens epithelial cell proliferation.

Investigative ophthalmology & visual science • 1998
View 7 Excerpts
Highly Influenced

The lens influences aqueous humor levels of transforming growth factor-beta 2.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie • 1998
View 17 Excerpts
Highly Influenced

Cataract induction in lenses cultured with transforming growth factor-beta.

Investigative ophthalmology & visual science • 1995
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…