The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

@article{Zingg2015TheEM,
  title={The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.},
  author={Daniel Zingg and Julien Debbache and Simon M. Schaefer and Eylul Tuncer and Sandra C Frommel and Phil F. Cheng and Natalia Arenas-Ramirez and Jessica Haeusel and Yudong Zhang and Mario Bonalli and Michael T McCabe and Caretha L Creasy and Mitchell P Levesque and Onur Boyman and Raffaella Santoro and Olga Shakhova and Reinhard Dummer and Lukas Sommer},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={6051}
}
Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. However, evidence for a functional role of EZH2 in tumorigenesis in vivo remains poor, in particular in metastasizing solid cancers. Here we reveal central roles of EZH2 in promoting growth and metastasis of cutaneous melanoma. In a melanoma mouse model, conditional Ezh2 ablation as much as treatment with the preclinical EZH2 inhibitor GSK503 stabilizes the disease through inhibition of growth and… CONTINUE READING
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