The epigenetic control of antigenic variation in Plasmodium falciparum.

  title={The epigenetic control of antigenic variation in Plasmodium falciparum.},
  author={Stuart A. Ralph and Artur Scherf},
  journal={Current opinion in microbiology},
  volume={8 4},
Much of what is known about antigenic variation in the human malaria parasite Plasmodium falciparum has been established by the study of phenotypic changes at the surface of parasitized red blood cells. Although this has contributed to our fundamental understanding of immune escape, nothing conclusive has been elucidated about the molecular mechanisms that determine activation and silencing of members of the antigenic variation var gene family. Recent findings indicate that reversible chromatin… CONTINUE READING

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