The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

@inproceedings{Marioni2015TheEC,
  title={The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936},
  author={Riccardo E. Marioni and Sudhir V. Shah and Allan F. McRae and S. J. Ritchie and Graciela Muniz-Terrera and Sarah E Harris and Jude Gibson and Paul M. Redmond and Simon R. Cox and Goran Papenberg and Janie Corley and Adele M Taylor and Lee Murphy and John M. Starr and Steve Horvath and Peter M. Visscher and Naomi R Wray and Ian J. Deary},
  booktitle={International journal of epidemiology},
  year={2015}
}
BACKGROUND The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability. METHODS DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Longitudinal changes in leukocyte telomere length and mortality in humans.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2014
VIEW 1 EXCERPT

A Language and Environment for Statistical Computing

R R Core Team
  • Vienna: R Foundation for Statistical Computing,
  • 2013

lme4: Linear Mixed-effects Models Using Eigen and S4. R package version 1.0-4

D Bates, M Maechler, B Bolker, S. Walker
  • www.r-project.org (September
  • 2013

lmerTest: Tests for Random and Fixed Effects for Linear Mixed Effect. R package version 2.0-0

A Kuznetsova, PB Brockhoff, RHB. Christensen
  • www.r-project.org (September
  • 2013

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