The epididymis and sperm maturation: a perspective.

@article{Amann1993TheEA,
  title={The epididymis and sperm maturation: a perspective.},
  author={Rupert P. Amann and Roy H. Hammerstedt and D. N. Rao Veeramachaneni},
  journal={Reproduction, fertility, and development},
  year={1993},
  volume={5 4},
  pages={
          361-81
        }
}
In common mammals, sperm leaving the testis are incapable of fertilizing a female gamete. Sperm have limited biosynthetic capability and need to minimize demand for ATP. Hence, modification of sperm to achieve their maturation requires pre-programmed cleavage of integral molecules (planned self-modification) and remodelling by action of molecules found in the suspending fluids. Most of these biocatalysts are secreted by a series of specialized regions in the epididymal epithelium, but some are… 
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    Advances in experimental medicine and biology
  • 1995
TLDR
This article reviews recent knowledge about events occurring in the epididymis that are important for sperm to fertilise eggs and attempts to bring the epidIDymal sperm-epithelial secretion into focus.
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Epididymal Cell Types and Their Functions
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The mammalian epididymis is a highly coiled duct that links the efferent ducts to the vas deferens and plays an important role in sperm transport, concentration, protection, and storage.
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TLDR
There is thus a development of the ability to respond to the ionophore upon maturation in monkey epididymal sperm, which can serve as a model for the study of human sperm maturation.
Functional maturation of mouse epididymal spermatozoa
TLDR
Research into the biochemical basis of sperm epididymal maturation revealed that this process was associated with the activation of sperm mitochondria, leading to the creation of a mitochondrial membrane potential (MMP) and activation of mitochondrial free radical generation.
Histological effects of androgen deprivation on the adult chimpanzee epididymis.
Primate sperm acquire functional maturity, including vigorous forward motility and the ability to fertilize an ovum, as they transit the unique, regional microenvironment of the epididymal lumen.
The epididymis-specific antimicrobial peptide β-defensin 15 is required for sperm motility and male fertility in the rat (Rattus norvegicus)
TLDR
It is shown that the rat epididymis-specific β-defensin 15 (Defb15) exhibits an androgen-dependent expression pattern, and it can bind to the acrosomal region of caput sperm, suggesting that Defb15 plays a dual role in both sperm maturation and pathogen defense in rat epidIDymis.
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