The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas.

@article{Li2010TheEG,
  title={The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas.},
  author={Gordon Li and Siddhartha Mitra and Albert J. Wong},
  journal={Neurosurgery clinics of North America},
  year={2010},
  volume={21 1},
  pages={87-93}
}
Epidermal growth factor variant III (EGFRvIII) is the most common alteration of the epidermal growth factor (EGF) receptor found in human tumors. It is commonly expressed in glioblastoma multiforme (GBM), where it was initially identified. This constitutively active mutant receptor leads to unregulated growth, survival, invasion, and angiogenesis in cells that express it. EGFRvIII results from an in-frame deletion of exons 2 to 7 resulting in the fusion of exon 1 to exon 8 of the EGF receptor… CONTINUE READING

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