The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells.

@article{Dahl2009TheEG,
  title={The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells.},
  author={Karen D Cowden Dahl and Richard Dahl and Jessica N. Kruichak and Laurie G. Hudson},
  journal={Neoplasia},
  year={2009},
  volume={11 11},
  pages={1208-15}
}
The epithelial-to-mesenchymal transition (EMT) that occurs during embryonic development is recapitulated during tumor metastasis. Important regulators of this process include growth factors, transcription factors, and adhesion molecules. New evidence suggests that microRNA (miRNA) activity contributes to metastatic progression and EMT; however, the mechanisms leading to altered miRNA expression during cancer progression remain poorly understood. Importantly, overexpression of the epidermal… CONTINUE READING

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