The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.

@article{Hazan1998TheEG,
  title={The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.},
  author={Rachel B. Hazan and Larry Norton},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 15},
  pages={9078-84}
}
Alterations in the expression or function of molecules that affect cellular adhesion and proliferation are thought to be critical events for tumor progression. Loss of expression of the cell adhesion molecule E-cadherin and increased expression of the epidermal growth factor receptor are two prominent molecular events that are associated with tumorigenesis. The regulation of E-cadherin-dependent cell adhesion by epidermal growth factor (EGF) was therefore examined in the human breast cancer… CONTINUE READING
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E-cadherin Interaction with the Actin Cytoskeleton

  • J. Weekes, S. T. Barry, D. R. Critley
  • J. Biol. Chem
  • 1996

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