The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.

  title={The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.},
  author={Ana Pardo-Saganta and M. Latasa and J. Castillo and L. Alvarez-Asiain and M. J. Perugorria and P. Sarobe and C. Rodr{\'i}guez-Ortigosa and J. Prieto and C. Berasain and M. Santamar{\'i}a and M. Avila},
  journal={Journal of hepatology},
  volume={51 6},
  • Ana Pardo-Saganta, M. Latasa, +8 authors M. Avila
  • Published 2009
  • Biology, Medicine
  • Journal of hepatology
  • BACKGROUND/AIMS The modulation of the hepatic acute-phase reaction (APR) that occurs during inflammation and liver regeneration is important for allowing normal hepatocellular proliferation and the restoration of homeostasis. Activation of acute-phase protein (APP) gene expression by interleukin-6 (IL-6)-type cytokines is thought to be counteracted by growth factors released during hepatic inflammation and regeneration. The epidermal growth factor receptor (EGFR) ligand amphiregulin (AR) is… CONTINUE READING
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