The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.

@article{PardoSaganta2009TheEG,
  title={The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.},
  author={Ana Pardo-Saganta and Mar{\'i}a Ujue Latasa and Josefa Bell Castillo and Laura Alvarez-Asiain and Mar{\'i}a J Perugorria and Pablo Sarobe and Carlos M. Rodr{\'i}guez-Ortigosa and Jes{\'u}s Prieto and Carmen Berasain and Monica Rut Sandoval Santamaria and Matias A Avila},
  journal={Journal of hepatology},
  year={2009},
  volume={51 6},
  pages={
          1010-20
        }
}
BACKGROUND/AIMS The modulation of the hepatic acute-phase reaction (APR) that occurs during inflammation and liver regeneration is important for allowing normal hepatocellular proliferation and the restoration of homeostasis. Activation of acute-phase protein (APP) gene expression by interleukin-6 (IL-6)-type cytokines is thought to be counteracted by growth factors released during hepatic inflammation and regeneration. The epidermal growth factor receptor (EGFR) ligand amphiregulin (AR) is… CONTINUE READING
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