The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.

@article{Prenzel2001TheEG,
  title={The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.},
  author={Norbert Prenzel and Oliver Martin Fischer and Sylvia Streit and Stefan Hart and Axel Ullrich},
  journal={Endocrine-related cancer},
  year={2001},
  volume={8 1},
  pages={11-31}
}
Homeostasis of multicellular organisms is critically dependent on the correct interpretation of the plethora of signals which cells are exposed to during their lifespan. Various soluble factors regulate the activation state of cellular receptors which are coupled to a complex signal transduction network that ultimately generates signals defining the required biological response. The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases represents both key regulators of… CONTINUE READING
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