The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation.

@article{Yu2009TheED,
  title={The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation.},
  author={Zhengquan Yu and Jaana Mannik and Amelia Soto and Kevin H. Lin and Bogi Andersen},
  journal={The EMBO journal},
  year={2009},
  volume={28 13},
  pages={1890-903}
}
Skin and bladder epithelia form effective permeability barriers through the activation of distinct differentiation gene programs. Using a genome-wide gene-expression study, we identified transcriptional regulators whose expression correlates highly with that of differentiation markers in both the bladder and skin, including the Grainyhead factor Get1/Grhl3, which is already known to be important for epidermal barrier formation. In the bladder, Get1 is most highly expressed in the differentiated… CONTINUE READING

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