The epidemiology of hepatoblastoma

  title={The epidemiology of hepatoblastoma},
  author={Logan G. Spector and Jill Birch},
  journal={Pediatric Blood \& Cancer},
Few causes of hepatoblastoma have been conclusively identified, mainly due to the extreme rarity of the disease. Inherited conditions including Familial Adenomatous Polyposis and Beckwith–Wiedemann Syndrome dramatically raise risk of hepatoblastoma but account for few cases overall. A small number of case–control studies investigating risk factors for sporadic hepatoblastoma have been conducted to date. Although most of these studies feature fewer than 200 cases, several clues have emerged… 
Hepatoblastoma in a Child With Early-onset Cirrhosis.
A young patient with cirrhosis attributed to early-onset hereditary hemochromatosis who was diagnosed with hepatoblastoma with uncommon histologic findings, evidence of chemotherapy resistance who ultimately succumbed to her disease is described.
Polycystic liver coexistent with hepatoblastoma : a case report of misdiagnosis
A 14 years old girl with hepatoblastoma misdiagnosed with polycystic liver with intracystic infection and hemorrhage is reported, finding the malignant tumor should be discovered earlier and confirmed to improve the prognosis.
Hepatoblastoma and Wolf–Hirschhorn syndrome: Coincidence or a new feature of a rare disease?
A pediatric patient with Wolf–Hirschhorn syndrome who developed hepatoblastoma is reported, which is a rare case and is not a frequent feature of the syndrome.
Hepatoblastoma in Explanted Livers of Patients With Biliary Atresia
In this cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses.
Hepatoblastoma in a 15‐month‐old female with trisomy 13
This is the first reported case of hepatoblastoma in a child with constitutional T13, and may represent a non‐random association, as somatic trisomy of chromosome 13 in hepatOBlastoma tumors has been previously described in the literature.
Hepatoblastoma in Infants Born to Parents with Familial Adenomatous Polyposis
The history, genetic basis, and treatment of HB in general and in patients with FAP are described and the potential benefits of early genetic testing for FAP and image-based screening for HB in infants born to parents with APC gene mutations are discussed.
Hepatoblastoma Arising in a Pigmented &bgr;-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature
A unique case of hepatoblastoma arising in a background of 2 &bgr;-catenin-activated HCAs, one of which is pigmented, in a 4-year-old child and the first case of a P-HCA in a child is presented.
Role of liver transplantation in the management of hepatoblastoma in the pediatric population.
It was found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras.
Hepatoblastoma in an 11-year-old
The case of a patient who was diagnosed with hepatoblastoma at an atypical age of presentation for this type of malignancy, who later had disease recurrence and after undergoing treatment with different modalities, ultimately died of his disease.
Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma
These rare syndromes with at least a 1% risk to develop these tumors and uniform tumor screening recommendations for North America are outlined and designed to be a broad framework within which physicians and families can work together to implement specific screening.


Hepatoblastoma in the Nordic countries
It is indicated that intrauterine and/or neonatal factors are associated with increased risk of hepatoblastoma, which may include low birth weight and asphyxia leading to neonatal intensive care.
Hepatitis virus B is not a risk factor in hepatoblastoma patients.
  • V. Wiwanitkit
  • Medicine
    Asian Pacific journal of cancer prevention : APJCP
  • 2005
No correlation between prevalence rate and nationality of the studied population and hepatitis B infection does not appear to be a contributing factor for hepatoblastoma, and further studies are needed to clarify which are the risk factors for the liver cancer.
Hepatoblastoma and low birth weight
An updated estimate of the rate of increase of HB incidence in the United States and its association with a rise in the proportion of births that are low (%LBW: 1,500–2,500 g) and especially very low birth weight (%VLBW):<1, 500 g is provided to provide an updated estimate.
Germline APC Mutations Are Not Commonly Seen in Children With Sporadic Hepatoblastoma
No germline APC mutations were found, which does not support the need for routine screening in sporadic hepatoblastoma in the absence of a suggestive family history of colorectal cancer or suspicion of familial adenomatous polyposis.
Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18: a case report
Careful clinical and post-mortem studies are needed to recognize the real frequency of hepatoblastoma in children with trisomy 18, who might die from different causes with unrecognizable hepatOBlastoma.
Risk of hepatoblastoma in familial adenomatous polyposis.
Hepatoblastoma and heart transplantation in a patient with cardio‐facio‐cutaneous syndrome
This report reports on a 3‐year‐old boy who underwent a cardiac transplant at age 8 months for hypertrophic cardiomyopathy and died shortly thereafter, and his post‐mortem DNA analysis revealed a MEK1 mutation previously reported in CFC, making this the first case of a solid tumor reported in a patient with CFC.
[Retrospective analysis of maternal and infant birth features of hepatoblastoma patients].
Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.