The epidemiology of hepatoblastoma

@article{Spector2012TheEO,
  title={The epidemiology of hepatoblastoma},
  author={Logan G. Spector and Jill Birch},
  journal={Pediatric Blood \& Cancer},
  year={2012},
  volume={59}
}
Few causes of hepatoblastoma have been conclusively identified, mainly due to the extreme rarity of the disease. Inherited conditions including Familial Adenomatous Polyposis and Beckwith–Wiedemann Syndrome dramatically raise risk of hepatoblastoma but account for few cases overall. A small number of case–control studies investigating risk factors for sporadic hepatoblastoma have been conducted to date. Although most of these studies feature fewer than 200 cases, several clues have emerged… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It was found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras.
Hepatoblastoma in an 11-year-old
TLDR
The case of a patient who was diagnosed with hepatoblastoma at an atypical age of presentation for this type of malignancy, who later had disease recurrence and after undergoing treatment with different modalities, ultimately died of his disease.
Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma
TLDR
These rare syndromes with at least a 1% risk to develop these tumors and uniform tumor screening recommendations for North America are outlined and designed to be a broad framework within which physicians and families can work together to implement specific screening.
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References

SHOWING 1-10 OF 59 REFERENCES
Hepatoblastoma in the Nordic countries
TLDR
It is indicated that intrauterine and/or neonatal factors are associated with increased risk of hepatoblastoma, which may include low birth weight and asphyxia leading to neonatal intensive care.
Hepatitis virus B is not a risk factor in hepatoblastoma patients.
  • V. Wiwanitkit
  • Medicine
    Asian Pacific journal of cancer prevention : APJCP
  • 2005
TLDR
No correlation between prevalence rate and nationality of the studied population and hepatitis B infection does not appear to be a contributing factor for hepatoblastoma, and further studies are needed to clarify which are the risk factors for the liver cancer.
Hepatoblastoma and low birth weight
TLDR
An updated estimate of the rate of increase of HB incidence in the United States and its association with a rise in the proportion of births that are low (%LBW: 1,500–2,500 g) and especially very low birth weight (%VLBW):<1, 500 g is provided to provide an updated estimate.
Germline APC Mutations Are Not Commonly Seen in Children With Sporadic Hepatoblastoma
TLDR
No germline APC mutations were found, which does not support the need for routine screening in sporadic hepatoblastoma in the absence of a suggestive family history of colorectal cancer or suspicion of familial adenomatous polyposis.
Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18: a case report
TLDR
Careful clinical and post-mortem studies are needed to recognize the real frequency of hepatoblastoma in children with trisomy 18, who might die from different causes with unrecognizable hepatOBlastoma.
Risk of hepatoblastoma in familial adenomatous polyposis.
Hepatoblastoma and heart transplantation in a patient with cardio‐facio‐cutaneous syndrome
TLDR
This report reports on a 3‐year‐old boy who underwent a cardiac transplant at age 8 months for hypertrophic cardiomyopathy and died shortly thereafter, and his post‐mortem DNA analysis revealed a MEK1 mutation previously reported in CFC, making this the first case of a solid tumor reported in a patient with CFC.
[Retrospective analysis of maternal and infant birth features of hepatoblastoma patients].
TLDR
Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.
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