The epidemiology of dementia associated with Parkinson disease

  title={The epidemiology of dementia associated with Parkinson disease},
  author={Dag Aarsland and Martin W. Kurz},
  journal={Journal of the Neurological Sciences},
  • D. Aarsland, M. Kurz
  • Published 15 February 2010
  • Psychology, Medicine, Biology
  • Journal of the Neurological Sciences

Crossover between Lewy Body Pathology and Alzheimer ’ s Dementia

Clinical predictors of PDD are old age, severity of motor symptoms, in particular postural and gait disturbances, mild cognitive impairment, visual hallucinations and male gender.

Cognitive decline in Parkinson’s disease: the complex picture

Evidence from neuroimaging studies using different methods and techniques suggests that in addition to degeneration of the dopaminergic system, other mechanisms have a role including β-amyloid and tau deposition, and that specific cognitive scales could help identifying a malignant profile.

Structural Neuroimaging Markers of Cognitive Decline in Parkinson's Disease

This review aims to outline the neuroimaging possibilities in diagnosing cognitive impairment in patients with Parkinson's disease and to take into consideration the near-future possibilities of their implementation into clinical practice.

Mild cognitive impairment in patients with Parkinson’s disease: An updated mini-review and future outlook

The diagnostic criteria for PD-MCI is overviewed, primarily focused on the heterogeneity of PD- MCI patients’ cognitive function, including various types of cognitive functions and their progression rates, and the unmet needs and future vision in this field are discussed.

Cognitive Impairment and Dementia in Parkinson’s Disease: Clinical Features, Diagnosis, and Management

This manuscript has synthesized relevant data in order to obtain a pragmatic and updated review regarding cognitive decline in PD, from milder stages to dementia.

Predictors of dementia in Parkinson disease

Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.

If I only had a brain : Epidemiological Studies of Parkinson's disease

The overall aim of this thesis was to increase the understanding of the etiology of PD and of the causes of comorbidity of parkinsonism and dementia.

Genetic characterization of cognitive impairment in Parkinson's disease.

A detailed characterization of cognitive impairment in Parkinson’s disease is performed, showing that impairments in tasks involving executive, visuospatial and memory functions are common in newly diagnosed patients, and that the impairments are associated with specific abnormalities in regional brain activation.

Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease.




Dementia associated with Parkinson's disease

  • M. Emre
  • Psychology, Biology
    The Lancet Neurology
  • 2003

Dementia and survival in Parkinson disease

Dementia is a key part of survival in Parkinson disease and must be planned for in services for this condition according to Diagnostic and Statistical Manual of Mental Disorders Third Edition, Revised criteria.

Cognitive Predictors of Dementia in Parkinson’s Disease: A Community-Based, 4-Year Longitudinal Study

It was concluded that poor performance on a test sensitive to executive dysfunction predicted later development of dementia in PD patients, and this finding may have important clinical implications as a marker of subsequentDevelopment of dementia.

Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study.

Early hallucinations and akinetic-dominant PD were associated with an increased risk of dementia, and more than three quarters of this representative PD cohort developed dementia during the 8-year study period.

Risk of dementia in Parkinson’s disease

Patients with PD have an almost sixfold increased risk for becoming demented compared with subjects without PD.

The frequency and associated risk factors for dementia in patients with Parkinson's disease.

Patients with PD, especially those with severe extrapyramidal signs, have almost twice the risk for the development of dementia than do community-dwelling control subjects.

A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease

Dementia in PD is likely to reflect interaction of the neuropathology of the basal ganglia and age-related pathology, and the findings do not support the division of PD into early and late-onset cases.

A longitudinal of Parkinson's disease: clinical and neuropsychological correlates of dementia

The effect of age of onset of PD on risk of dementia

This study shows that the general effect of age, rather than AAO, is associated with incident dementia in subjects with PD, and there was no effect of AAO independent of age itself.

The relationship of Parkinson disease with aging.

  • G. Levy
  • Psychology, Medicine
    Archives of neurology
  • 2007
A model for the relationship between PD and aging is proposed that implies that understanding the degenerative process in nondopaminergic structures in PD as it relates to molecular mechanisms accompanying the aging of the nervous system may create opportunities for interventions affecting the clinical progression of the disease.