The epidemiology of ALS: a conspiracy of genes, environment and time

@article{AlChalabi2013TheEO,
  title={The epidemiology of ALS: a conspiracy of genes, environment and time},
  author={Ammar Al-Chalabi and Orla Hardiman},
  journal={Nature Reviews Neurology},
  year={2013},
  volume={9},
  pages={617-628}
}
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease of motor neurons, resulting in worsening weakness of voluntary muscles until death from respiratory failure occurs after about 3 years. Although great advances have been made in our understanding of the genetic causes of ALS, the contribution of environmental factors has been more difficult to assess. Large-scale studies of the clinical patterns of ALS, individual histories preceding the onset of ALS… 

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