The epidemiology of ALS: a conspiracy of genes, environment and time

  title={The epidemiology of ALS: a conspiracy of genes, environment and time},
  author={A. Al-Chalabi and O. Hardiman},
  journal={Nature Reviews Neurology},
  • A. Al-Chalabi, O. Hardiman
  • Published 2013
  • Medicine
  • Nature Reviews Neurology
  • Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease of motor neurons, resulting in worsening weakness of voluntary muscles until death from respiratory failure occurs after about 3 years. Although great advances have been made in our understanding of the genetic causes of ALS, the contribution of environmental factors has been more difficult to assess. Large-scale studies of the clinical patterns of ALS, individual histories preceding the onset of ALS… CONTINUE READING
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