The epidemiologic approach to pharmacogenomics.

  title={The epidemiologic approach to pharmacogenomics.},
  author={Julian Little and Linda Sharp and Muin J. Khoury and Linda Bradley and Marta Gwinn},
  journal={American journal of pharmacogenomics : genomics-related research in drug development and clinical practice},
  volume={5 1},
The epidemiologic approach enables the systematic evaluation of potential improvements in the safety and efficacy of drug treatment which might result from targeting treatment on the basis of genomic information. The main epidemiologic designs are the randomized control trial, the cohort study, and the case-control study, and derivatives of these proposed for investigating gene-environment interactions. However, no one design is ideal for every situation, and methodological issues, notably… CONTINUE READING

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