The ependymal route to the CNS: an emerging gene-therapy approach for MS.

@article{Martino2001TheER,
  title={The ependymal route to the CNS: an emerging gene-therapy approach for MS.},
  author={Gianvito Martino and Roberto Furlan and Giancarlo Comi and L. Adorini},
  journal={Trends in immunology},
  year={2001},
  volume={22 9},
  pages={483-90}
}
The systemic administration of anti-inflammatory molecules to patients affected by immune-mediated inflammatory demyelinating diseases of the central nervous system (CNS), such as multiple sclerosis, has limited therapeutic efficacy owing to the presence of the blood-brain barrier. The delivery of drugs to the CNS using a nonreplicative viral vector engineered with genes encoding anti-inflammatory cytokines might represent an alternative therapeutic strategy. Here, we propose accessing the CNS… CONTINUE READING

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