The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma.

@article{Frigas1991TheEI,
  title={The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma.},
  author={Evangelo Frigas and Sayaka Motojima and Gerald J. Gleich},
  journal={The European respiratory journal. Supplement},
  year={1991},
  volume={13},
  pages={123s-135s}
}
Eosinophilic bronchitis and desquamation of the bronchial mucosa are the salient features of the pathology of both allergic (extrinsic) and nonallergic (intrinsic) asthma. Because of this association, the possibility of the eosinophil being the cause of the injury to the bronchial mucosa has been investigated during the last decade. In vitro, eosinophil granule major basic protein (MBP) concentrations as low as 10 micrograms.ml-1 cause desquamation and destruction of the epithelium of the… CONTINUE READING

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