The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli.

@article{Wahba1962TheES,
  title={The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli.},
  author={A. J. Wahba and M E Friedkin},
  journal={The Journal of biological chemistry},
  year={1962},
  volume={237},
  pages={
          3794-801
        }
}
The formation of thymidine triphosphate in cell-free extracts of Escherichia coli was reported in 1957 to require deoxyuridylate, formaldehyde, dZ,n-tetrahydrofolate, Mg++, and adenosine triphosphate (1). It soon became apparent through use of chromatographic procedures that ATP was not involved in the primary conversion of deoxyuridylate to thymidylate, and that the over-all reaction could be represented as follows. 

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