The enzymatic function of tafazzin.

@article{Xu2006TheEF,
  title={The enzymatic function of tafazzin.},
  author={Yang Xu and Ashim Malhotra and Mindong Ren and Michael Schlame},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 51},
  pages={39217-24}
}
Tafazzin is a putative enzyme that is involved in cardiolipin metabolism, it may carry mutations responsible for Barth syndrome. To identify the biochemical reaction catalyzed by tafazzin, we expressed the full-length isoform of Drosophila melanogaster tafazzin in a baculovirus-Sf9 insect cell system. Tafazzin expression induced a new enzymatic function in Sf9 cell mitochondria, namely 1-palmitoyl-2-[14C]linoleoyl-phosphatidylcholine:monolysocardiolipin linoleoyltransferase. We also found… CONTINUE READING
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Tafazzin Function 39224 JOURNAL OF BIOLOGICAL CHEMISTRY

  • S. M. Claypool, J. M. McCaffery, C. M. Koehler
  • J. Cell Biol
  • 2006
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