The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.

@article{Lugassy2012TheEA,
  title={The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.},
  author={Jennie Lugassy and Shelly Zaffryar-Eilot and Sharon Soueid and Amit Mordoviz and Victoria Smith and Ofra Kessler and Gera Neufeld},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 5},
  pages={3541-9}
}
Lysyl oxidase-like-2 (LOXL2) induces tumor progression and fibrosis. It also inhibits the differentiation of keratinocytes promoting development of squamous cell carcinomas. Stimulation of HaCaT skin keratinocytes with exogenous LOXL2 or overexpression of LOXL2 in these cells inhibits their differentiation as manifested by inhibition of calcium or vitamin D-induced involucrin expression. The inhibition was abrogated by the LOXL2 function-blocking monoclonal antibody AB0023 as well as by an anti… CONTINUE READING