The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.

@article{Knaapen2007TheEC,
  title={The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.},
  author={Ad M. Knaapen and Dani{\"e}lle M. J. Curfs and Dani{\"e}lle M F A Pachen and Ralph W. H. Gottschalk and Menno P J de Winther and M J A P Daemen and Frederik-Jan van Schooten},
  journal={Mutation research},
  year={2007},
  volume={621 1-2},
  pages={31-41}
}
Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) has been implicated in the aetiology of atherosclerosis. Previously we showed that chronic exposure of ApoE-/- mice to the prototype PAH benzo[a]pyrene (B[a]P) causes enhanced progression of atherosclerosis, which was characterised by an increased inflammatory cell content in the atherosclerotic plaques. The aim of the present study was to evaluate the effect of B[a]P on vascular expression of monocyte-chemoattractant protein 1… CONTINUE READING
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