The entity of immunoglobulin A-related anaphylactic transfusion reactions is not evidence based.


In 1968, Vyas and colleagues described three immunoglobulin (Ig)A-deficient patients with “alarming transfusion reactions” after administration of whole blood, plasma, or gamma globulin. Sera from these patients agglutinated eight IgA multiple myeloma–coated reagent red blood cells (RBCs), fulfilling the authors’ criterion for an anaphylactic reaction… (More)
DOI: 10.1111/trf.12796


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