The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.

Abstract

The novel enterovirus protease inhibitor (PI) SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B (median 50% effective concentration, 0.04 μM). A low-level SG85-resistant variant was selected that carried amino acid substitutions S127G and T143A in the 3C protease. Both substitutions are required for low… (More)
DOI: 10.1128/AAC.00534-15

Topics

Cite this paper

@article{Lacroix2015TheE3, title={The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.}, author={C{\'e}line Lacroix and Shyla George and Pieter Leyssen and Rolf Hilgenfeld and Johan Neyts}, journal={Antimicrobial agents and chemotherapy}, year={2015}, volume={59 9}, pages={5814-8} }