The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.

@article{Vergnolle2003TheEN,
  title={The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.},
  author={Nathalie Vergnolle},
  journal={Canadian journal of gastroenterology = Journal canadien de gastroenterologie},
  year={2003},
  volume={17 10},
  pages={589-92}
}
The enteric nervous system (ENS) plays a pivotal role in inflammatory and nociceptive processes. Drugs that interact with the ENS have recently raised considerable interest because of their capacity to regulate numerous aspects of the gut physiology and pathophysiology. The present article summarizes recent research on proteinases and proteinase-activated receptors (PARs) as signalling molecules in the ENS. In particular, experiments in animal models suggest that PAR2 is important to neurogenic… CONTINUE READING

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