The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.

@article{Rolf2005TheEP,
  title={The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.},
  author={Julia Rolf and Vin{\'i}cius Motta and N{\'a}dia Duarte and Marie Lundholm and Emma Berntman and M A Bergman and Lydia Sorokin and Susanna L Cardell and Dan Holmberg},
  journal={Journal of immunology},
  year={2005},
  volume={174 8},
  pages={4821-7}
}
The NOD mouse is an important experimental model for human type 1 diabetes. T cells are central to NOD pathogenesis, and their function in the autoimmune process of diabetes has been well studied. In contrast, although recognized as important players in disease induction, the role of B cells is not clearly understood. In this study we characterize different subpopulations of B cells and demonstrate that marginal zone (MZ) B cells are expanded 2- to 3-fold in NOD mice compared with nondiabetic… CONTINUE READING
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