The enigma of vascular cognitive disorder and vascular dementia

@article{Jellinger2006TheEO,
  title={The enigma of vascular cognitive disorder and vascular dementia},
  author={Kurt A. Jellinger},
  journal={Acta Neuropathologica},
  year={2006},
  volume={113},
  pages={349-388}
}
The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed vascular cognitive impairment, are a matter of discussion, and currently used clinical diagnostic criteria show moderate sensitivity (average 50%) and variable specificity (range 64–98%). In Western clinic-based series, VaD is suggested in 8–10% of cognitively impaired aged subjects. Its prevalence in autopsy series varies from 0.03 to 58%, with reasonable values of 8–15%, while in Japan it is seen in 22–35… CONTINUE READING

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Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
The prevalence , morphology and pathogenesis of vascular dementia ( VaD ) , recently termed vascular cognitive impairment , are a matter of discussion , and currently used clinical diagnostic criteria show moderate sensitivity ( average 50% ) and variable specificity ( range 64–98% ) .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
The prevalence , morphology and pathogenesis of vascular dementia ( VaD ) , recently termed vascular cognitive impairment , are a matter of discussion , and currently used clinical diagnostic criteria show moderate sensitivity ( average 50% ) and variable specificity ( range 64–98% ) .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
Neuropathologic changes associated with cognitive impairment include multifocal and/or diffuse disease and focal lesions : multi - infarct encephalopathy , white matter lesions or arteriosclerotic subcortical ( leuko)encephalopathy , multilacunar state , mixed cortico - subcortical type , borderline / watershed lesions , rare granular cortical atrophy , post - ischemic encephalopathy and hippocampal sclerosis .
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